Our Science

Our nimble and exploratory approach to R&D sets us apart and allows us to innovate faster than the competition

FEARLESS THINKING AND A ROUND-THE-CLOCK WORKFLOW

Aligned in the fight against cancer

OPENING THE THERAPEUTIC WINDOW TO SOLID TUMORS

Tumor Metabolism Regulated (TMR) CARs

In solid tumors, on-target, off-tumor toxicity to antigens expressed in healthy, normal tissue has limited the number of antigens available for effective targeting by cell therapies. However restricting CAR-T target engagement to the tumor could limit damage to healthy tissue and broaden the therapeutic window for maximum anti-tumor efficacy.

Our TMR CAR-T technology for solid tumors can potentially help avoid such toxicity, by using the tumor microenvironment to activate the CARs, turning them into the “ON” state.

ECONOMICALLY VIABLE, SAME-DAY AUTOLOGOUS CELL THERAPIES

Rapid point-of-care "rPOC" CAR-T

One of the major challenges facing CAR-T is the cost and complexity to deliver the therapy. At EXUMA Biotech, developing solutions that are not only safe and effective, but also accessible, is a part of our core values. We are applying science and innovation to improve access for these therapies through truly point-of-care treatments.

Our next-generation rapid point-of-care, or “rPOC”, platform is being developed for subcutaneous autologous CAR-T manufacturing in a matter of hours following blood draw. This platform could dramatically change the CAR-T landscape; eventually, rPOC could use the community oncology infusion clinic infrastructure and potentially be administered without lymphodepleting chemotherapy or long-term immunosuppression.

Our goal is to make treatment easier for cancer patients who need these potentially life-saving cell therapies, while reducing the fiscal burden across the healthcare system.

ANALYTICS

Testing systems that provide unbiased answers

While some companies may select top leads from a pool of five to ten candidates, our proprietary analytics platforms help scientists find the best leads from hundreds of thousands of CARs and components.