A Novel Conditionally Active Biologics Approach to Minimize On-target Off-tumor Effects in Adoptive Immunotherapy
AACR 2019 Abstract #3189 Link to poster Key Messages: We describe a novel approach to minimize on-Target off-tumor effects in CAR-T cell therapy in solid tumor We developed CAB-CARs by exploiting the unique property of TME that is an acidic extracellular pH environment Our CAB-CAR-T cells display “AND logic gate” properties, requiring both antigen […]
CAB-CAR-T: The Prioritization of Cell Surface Protein Targets for Conditionally Active Biologics to Treat All Solid Tumors
AACR 2019 Abstract #5101 Link to poster Key Messages: With the advent of Chimeric Antigen Receptor (CAR) T cell therapy to treat cancer, a new category of targetable biomarkers has emerged that are associated with the surface of malignant cells and serve as targets for cytotoxic T cells By modeling target mRNA expression from […]
A High-Throughput Screening Strategy for the Identification of Novel Lymphoproliferative Elements
AACR Abstract #3523 Link to poster Key Messages: The current work describes a high-throughput method for screening lymphoproliferative elements in vivo in a lentivirus format for next generation CAR-T therapies By quantification of selectively enriched human PBMCs we can identify combinatorial elements that promote CAR-T cell expansion and survival in an in vivo mouse model Our platform is robust, and also able to identify previously published lymphoproliferative elements (such as MyD88) as well as new, potent combinations of elements that are both dependent or independent […]
Keynote Announcement: BioFlorida Conference 2018
Morning General Session Speaker Monday, Oct. 15 from 8:55 AM – 9:35 AM Link to full posting
