AACR 2019 Abstract #3189
Key Messages:
- We describe a novel approach to minimize on-Target off-tumor effects in CAR-T cell therapy in solid tumor
- We developed CAB-CARs by exploiting the unique property of TME that is an acidic extracellular pH environment
- Our CAB-CAR-T cells display “AND logic gate” properties, requiring both antigen presence and TME conditions for optimized activity
- Our CAB-CAR technology provides an opportunity to develop safer CAR-T therapeutics for solid tumor
- By leveraging this technology, we can develop CARs against a wider range of antigens that were previously un-targetable, such as ones present in normal tissues
